Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• had a long-term effect due to the stability of EGCG. The findings of the study underline the potential of antioxidant and antiaging effects of the developed ethosomal formulations for use in the cosmetic field. Keywords: antioxidant effect; antiaging effect; epigallocatechin gallate; ethosomal gel

• obtained in the F3-coded ETH. Afterward, the ethosomal gel formulation was prepared by dispersing the F3 formulation in 1% (w/v) Carbopol 980 gel. Next, its organoleptic properties (i.e., color and homogeneity), viscosity and rheological properties, and pH values were evaluated. It was found suitable to

• use Carbopol 980 as the gelling agent at a ratio of 1:1 (v/v) due to its suitable organoleptic properties, pH value, viscosity, and its ability to homogeneously mix with the ethosome. A transparent, homogeneous, and smooth ethosomal gel system with a skin-compatible pH value (5.60) was obtained (Table